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Lactobacillus can not only improve intestinal health, but also prevent influenza!

Release time:2018-01-04

Researchers from Georgia State University recently found that lactic acid bacteria commonly used as beneficial bacteria to improve the intestinal health of the body or can provide the body with a protective effect against infection with different influenza A virus subtypes, eventually leading to the body in the virus infection weight loss, while reducing the level of replication of the lung virus, the relevant research published in the Scientific magazine on the international magazine.


Influenza virus can cause serious respiratory diseases in humans. Although researchers have developed seasonal influenza vaccines, during the pandemic flu, influenza virus infection will cause 3 million to 5 million people worldwide. Between 250,000 and 500,000 people were reported to have died of the flu virus;Epidemics and airborne infections can rapidly trigger the onset of serious illnesses, a leading cause of death in many patients worldwide, the vaccine works effectively to protect the body from infection only if the vaccine strain is compatible with the pandemic influenza virus.


Influenza A viruses infect humans, birds and pigs. Influenza A viruses are subdivided into many different subtypes depending on the hemagglutinin (HA) and neuraminidase (NA) proteins on the surface of the virus.Currently, researchers have identified 18 different hemagglutinins and 11 different neuraminidase enzymes, which indicates that different hemagglutinin and neuraminidase enzymes produce different types of virus combinations, and therefore, to find an effective way is important to provide people with a broad range of protection against influenza virus infection (regardless of subtypes).


In the article, researchers pre-treated mice with DK128 and subsequently infected mice with influenza A virus. The results showed that various immune responses in mice were directly related to the resistance to influenza virus, including increased levels of alveolar phagocytes in the lungs and respiratory tract of mice, early induction of virus-specific antibodies, and decreased levels of proinflammatory cytokines and innate immune cells.In addition, the mouse body has also been produced that can effectively resist the subtype of other virus-induced secondary influenza virus infection immunity.


Sang-Moo Kang, a researcher, said that we found that pretreating mice with heat-inactivated L. casei DK128 would make them resistant to lethal primary and secondary influenza virus infections, and protect mice against weight loss and death; these findings are important because pretreatment of mice with DK128 results in 100% survival and prevents weight loss. Lactobacillus casei also confers cross-immunoprotection in mice against mice susceptible to influenza virus infection Secondary fatal infections, the protection against influenza virus may not be targeted against a specific strain of influenza virus. Our study provides relevant evidence that heated inactivated L. casei may be able to counteract unspecific influenza virus infections by nasal spray as a prophylactic drug.